Collaborations & Partnerships

We have developed a Pain and Childhood Adversity questionnaire for us in the LBC1936 cohort. This has been completed by 225 of the participants is is now undergoing analysis.

2022 (and still active)

We are linking MRI datasets in Generation Scotland, Lothian Birth Cohort 1936 and Juvanile Ideopathic Arthritis patients to pain outcomes looking for biomarkers of vulnerability. This involves linkage, analysis and quality control.

2023 (still active)

Led by Professor Gary Macfarlane: Identification of qualitative literature assessing the relationship between adverse events in childhood and chronic widespread pain in adults using a search strategy in public datasets.

2024 (still active)

Further Fundings

Arthritis UK

This is an extension of work started by CAPE


Research Datasets, database and Models

The dataset was collected as part of the CAPE study. It consists of pseudonymised data in 75 young adults with Juvenile Idiopathic Arthritis who have either high or low persistent pain. It includes: – detailed pain history. – multiple patient-reported outcome measures based on validated questionnaires assessing adverse childhood experiences, quality of life, function, psychosocial and cognitive factors. – Quatitative Sensory Testing data (QST; 13 measures + CPM task) assessing somatosensory function and sensitivity across a range of joints and muscles. – brain MRI data (T1, resting state fMRI, diffusion MRI, task fMRI: Reward task and Fearful Faces task). Collecting a broad range of information is important for increasing understanding of difficult-to-manage chronic pain. The dataset will be made publicly available after it has been finalised and initial results published.

Publications

The impact of adverse childhood experiences on DNA methylation age: a systematic review and meta-analysis.

Published in:  Clinical Epigenetics, January 2026

Authors: Hannah Russell, Gregor Angus, Sam Singleton, Christopher G. Bell & Tim G. Hales

Published in:  2025

Authors: Antoniou G, Smith B, Romaniuk L, Whalley H, McIntosh A, Waiter G, Hales T, Steele J, Colvin L

Alleviate Pain Data Hub: Making Chronic Pain Data Discoverable and Reusable

Published in:  2025

Authors:  Milligan G, Masood E, Appleby P, Smith B, Colvin L, Hales T, Fisher J, Villalon A, Urwin E, Quinlan P, Cole C

Published in:

Authors:  Morgan O, Singleton S, Florea R, Hestehave S, Sarter T, Wozniak E, Mein C, Hausch F, Bell C, Géranton S

Published in:  2025

Authors:  Mosler F, Christogianni A, Singleton S, Hales T, Rennie J, Colvin L, Caes L

Journal Title:  Frontiers in aging

Published in:  2025

Authors: Senaratne DNS, Singleton S, Timmins K, Spiteri J, Redmond P, Taylor A, Corley J, Page D, Rennie J, Wang H, Verriotis M, Walker SM, Sen D, Macfarlane GJ, Colvin LA, Caes L, Cox SR, Hales TG

Impact of adverse childhood experiences on analgesia-related outcomes: a systematic review.

Journal Title:  British journal of anaesthesia

Published:  2025

Authors:  Senaratne DNS, Koponen M, Barnett KN, Smith BH, Hales TG, Marryat L, Colvin LA

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Journal Title:   British journal of anaesthesia

Published in:  2025

Authors: Taylor HE, Salf JC, Roper-Marchand CR, Senaratne DNS, Smith BH, Colvin LA, George J

Adverse Childhood Experiences and Health at Age 50 Years in the National Child Development Study.

Journal Title:   JAMA network open

Published in:  2025

Authors:  Timmins KA, MacDonald R, Beasley M, Macfarlane GJ

Childhood maltreatment and chronic “all over” body pain in adulthood: a counterfactual analysis using UK Biobank.

Journal Title:  Pain

Published in: 2025

Authors:  Timmins KA, Hales TG, Macfarlane GJ, Consortium Against Pain InEquality (CAPE) investigators and Chronic Pain Advisory Group

Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA Suicidal Thoughts and Behaviours consortium

Journal Title: Translational Psychiatry

Published in:  2025

Authors: van Velzen L, Colic L, Ceja Z, Dauvermann M, Villa L, Savage H, Toenders Y, Dehestani N, Zhu A, Campos A, Salminen L, Alda M, Agartz I, Alexander N, Ayesa-Arriola R, Ballard E, Banaj N, Barkhau C, Başgöze Z, Bauer J, Benedetti F, Berger K, Besteher B, Brosch K, Canal-Rivero M, Cervenka S, Colle R, Connolly C, Corruble E, Courtet P, Couvy-Duchesne B, Crespo-Facorro B, Cullen K, Dannlowski U, Deverdun J, Diaz-Zuluaga A, Dietze L, Evans J, Fani N, Flinkenflügel K, Friedman N, Gotlib I, Groenewold N, Grotegerd D, Hajek T, Hatoum A, Hermesdorf M, Hickie I, Hirano Y, Ho T, Ikemizu Y, Iorfino F, Ipser J, Isobe Y, Jackowski A, Jollant F, Kircher T, Klug M, Koopowitz S, Kraus A, Krug A, Le Bars E, Leehr E, Li M, Lippard E, Lopez-Jaramillo C, Maximov I, McIntosh A, McLaughlin K, McWhinney S, Meinert S, Melloni E, Mitchell P, Mwangi B, Nenadić I, Nerland S, Olie E, Ortiz-García de la Foz V, Pan P, Pereira F, Piras F, Piras F, Poletti S, Reineberg A, Roberts G, Romero-García R, Sacchet M, Salum G, Sandu A, Sellgren C, Shimizu E, Smolker H, Soares J, Steele J, Stein F, Stein D, Straube B, Teutenberg L, Thomas-Odenthal F, Usemann P, Valabregue R, Valencia-Echeverry J, Wagner G, Waiter G, Walter M, Whalley H, Wu M, Yang T, Zarate C, Zugman A, Zunta-Soares G, van Heeringen K, van Rooij S, van der Wee N, van der Werff S, Thompson P, Blumberg H, van Harmelen A, Rentería M, Jahanshad N, van Velzen L, Le Bars E, de la Foz V, van Heeringen K, van Rooij S, van der Wee N, van der Werff S, van Harmelen A, Schmaal L

Resting-state networks in chronic tinnitus: Increased connectivity between thalamus and visual areas.

Journal Title:  Hearing research

Published in: 2024

Authors:  Kok T, Varley R, Clark C, Verriotis M, Seunarine K, Shekhawat GS

Pharmacological interventions for remifentanil-induced hyperalgesia: A systematic review and network meta-analysis of preclinical trials.

Journal Title:  PloS one

Published in:  2024

Authors:  Koponen ME, Naray E, Hales TG, Forget P

ENIGMA-Chronic Pain: a worldwide initiative to identify brain correlates of chronic pain.

Journal Title: Pain

Published in:  2024

Authors:  Quidé Y, Jahanshad N, Andoh J, Antoniou G, Apkarian AV, Ashar YK, Badran BW, Baird CL, Baxter L, Bell TR, Blanco-Hinojo L, Borckardt J, Cheung CL, Ciampi de Andrade D, Couto BA, Cox SR, Cruz-Almeida Y, Dannlowski U, De Martino E, de Tommaso M, Deus J, Domin M, Egorova-Brumley N, Elliott J, Fanton S, Fauchon C, Flor H, Franz CE, Gatt JM, Gerdhem P, Gilman JM, Gollub RL, Govind V, Graven-Nielsen T, Håkansson G, Hales T, Haswell C, Heukamp NJ, Hu L, Huang L, Hussain A, Jensen K, Kircher T, Kremen WS, Leehr EJ, Lindquist M, Loggia ML, Lotze M, Martucci KT, Meeker TJ, Meinert S, Millard SK, Morey RA, Murillo C, Nees F, Nenadic I, Park HRP, Peng X, Ploner M, Pujol J, Robayo LE, Salan T, Seminowicz DA, Serian A, Slater R, Stein F, Stevens J, Strauss S, Sun D, Vachon-Presseau E, Valdes-Hernandez PA, Vanneste S, Vernon M, Verriotis M, Wager TD, Widerstrom-Noga E, Woodbury A, Zeidan F, Bhatt RR, Ching CRK, Haddad E, Thomopoulos SI, Thompson PM, Gustin SM

Journal Title:  BMC Medicine

Published in:  2024

Authors:  Senaratne DNS,

Thakkar B, Smith BH, Hales TG, Marryat L, Colvin LA

Journal Title:  Neuropharmacology

Published in:  2024

Authors:  Singleton S, Dieterle C, Walker DJ, Runeberg T, Oswald AS, Rosenqvist G, Robertson L, McCarthy T, Sarkar S, Baptista-Hon D, Hales TG

Early-life adversity increases morphine tolerance and persistent inflammatory hypersensitivity through upregulation of δ opioid receptors in mice.

Journal Title:  Pain

Published in: 2023

Authors:  Singleton S, Sneddon C, Bakina A, Lambert JJ, Hales TG