Collaborations & Partnerships
We have developed a Pain and Childhood Adversity questionnaire for us in the LBC1936 cohort. This has been completed by 225 of the participants is is now undergoing analysis.
2022 (and still active)
We are linking MRI datasets in Generation Scotland, Lothian Birth Cohort 1936 and Juvanile Ideopathic Arthritis patients to pain outcomes looking for biomarkers of vulnerability. This involves linkage, analysis and quality control.
2023 (still active)
Led by Professor Gary Macfarlane: Identification of qualitative literature assessing the relationship between adverse events in childhood and chronic widespread pain in adults using a search strategy in public datasets.
2024 (still active)
Further Fundings
Arthritis UK
This is an extension of work started by CAPE
Research Datasets, database and Models
The dataset was collected as part of the CAPE study. It consists of pseudonymised data in 75 young adults with Juvenile Idiopathic Arthritis who have either high or low persistent pain. It includes: – detailed pain history. – multiple patient-reported outcome measures based on validated questionnaires assessing adverse childhood experiences, quality of life, function, psychosocial and cognitive factors. – Quatitative Sensory Testing data (QST; 13 measures + CPM task) assessing somatosensory function and sensitivity across a range of joints and muscles. – brain MRI data (T1, resting state fMRI, diffusion MRI, task fMRI: Reward task and Fearful Faces task). Collecting a broad range of information is important for increasing understanding of difficult-to-manage chronic pain. The dataset will be made publicly available after it has been finalised and initial results published.
Publications
Published in: Clinical Epigenetics, January 2026
Authors: Hannah Russell, Gregor Angus, Sam Singleton, Christopher G. Bell & Tim G. Hales
Published in: March 2026
Authors: Senaratne DNS, Smith BH, Hales TG, Marryat L, Colvin LA
Published in: 2025
Authors: Antoniou G, Smith B, Romaniuk L, Whalley H, McIntosh A, Waiter G, Hales T, Steele J, Colvin L
Alleviate Pain Data Hub: Making Chronic Pain Data Discoverable and Reusable
Published in: 2025
Authors: Milligan G, Masood E, Appleby P, Smith B, Colvin L, Hales T, Fisher J, Villalon A, Urwin E, Quinlan P, Cole C
Published in:
Authors: Morgan O, Singleton S, Florea R, Hestehave S, Sarter T, Wozniak E, Mein C, Hausch F, Bell C, Géranton S
Published in: 2025
Authors: Mosler F, Christogianni A, Singleton S, Hales T, Rennie J, Colvin L, Caes L
Journal Title: Frontiers in aging
Published in: 2025
Authors: Senaratne DNS, Singleton S, Timmins K, Spiteri J, Redmond P, Taylor A, Corley J, Page D, Rennie J, Wang H, Verriotis M, Walker SM, Sen D, Macfarlane GJ, Colvin LA, Caes L, Cox SR, Hales TG
Impact of adverse childhood experiences on analgesia-related outcomes: a systematic review.
Journal Title: British journal of anaesthesia
Published: 2025
Authors: Senaratne DNS, Koponen M, Barnett KN, Smith BH, Hales TG, Marryat L, Colvin LA
.
Journal Title: BMJ open
Published in: 2025
Authors: Senaratne DNS, Smith BH, Hales TG, Marryat L, Colvin LA
Journal Title: British journal of anaesthesia
Published in: 2025
Authors: Taylor HE, Salf JC, Roper-Marchand CR, Senaratne DNS, Smith BH, Colvin LA, George J
Adverse Childhood Experiences and Health at Age 50 Years in the National Child Development Study.
Journal Title: JAMA network open
Published in: 2025
Authors: Timmins KA, MacDonald R, Beasley M, Macfarlane GJ
Journal Title: Pain
Published in: 2025
Authors: Timmins KA, Hales TG, Macfarlane GJ, Consortium Against Pain InEquality (CAPE) investigators and Chronic Pain Advisory Group
Journal Title: Translational Psychiatry
Published in: 2025
Authors: van Velzen L, Colic L, Ceja Z, Dauvermann M, Villa L, Savage H, Toenders Y, Dehestani N, Zhu A, Campos A, Salminen L, Alda M, Agartz I, Alexander N, Ayesa-Arriola R, Ballard E, Banaj N, Barkhau C, Başgöze Z, Bauer J, Benedetti F, Berger K, Besteher B, Brosch K, Canal-Rivero M, Cervenka S, Colle R, Connolly C, Corruble E, Courtet P, Couvy-Duchesne B, Crespo-Facorro B, Cullen K, Dannlowski U, Deverdun J, Diaz-Zuluaga A, Dietze L, Evans J, Fani N, Flinkenflügel K, Friedman N, Gotlib I, Groenewold N, Grotegerd D, Hajek T, Hatoum A, Hermesdorf M, Hickie I, Hirano Y, Ho T, Ikemizu Y, Iorfino F, Ipser J, Isobe Y, Jackowski A, Jollant F, Kircher T, Klug M, Koopowitz S, Kraus A, Krug A, Le Bars E, Leehr E, Li M, Lippard E, Lopez-Jaramillo C, Maximov I, McIntosh A, McLaughlin K, McWhinney S, Meinert S, Melloni E, Mitchell P, Mwangi B, Nenadić I, Nerland S, Olie E, Ortiz-García de la Foz V, Pan P, Pereira F, Piras F, Piras F, Poletti S, Reineberg A, Roberts G, Romero-García R, Sacchet M, Salum G, Sandu A, Sellgren C, Shimizu E, Smolker H, Soares J, Steele J, Stein F, Stein D, Straube B, Teutenberg L, Thomas-Odenthal F, Usemann P, Valabregue R, Valencia-Echeverry J, Wagner G, Waiter G, Walter M, Whalley H, Wu M, Yang T, Zarate C, Zugman A, Zunta-Soares G, van Heeringen K, van Rooij S, van der Wee N, van der Werff S, Thompson P, Blumberg H, van Harmelen A, Rentería M, Jahanshad N, van Velzen L, Le Bars E, de la Foz V, van Heeringen K, van Rooij S, van der Wee N, van der Werff S, van Harmelen A, Schmaal L
Journal Title: Hearing research
Published in: 2024
Authors: Kok T, Varley R, Clark C, Verriotis M, Seunarine K, Shekhawat GS
Journal Title: PloS one
Published in: 2024
Authors: Koponen ME, Naray E, Hales TG, Forget P
ENIGMA-Chronic Pain: a worldwide initiative to identify brain correlates of chronic pain.
Journal Title: Pain
Published in: 2024
Authors: Quidé Y, Jahanshad N, Andoh J, Antoniou G, Apkarian AV, Ashar YK, Badran BW, Baird CL, Baxter L, Bell TR, Blanco-Hinojo L, Borckardt J, Cheung CL, Ciampi de Andrade D, Couto BA, Cox SR, Cruz-Almeida Y, Dannlowski U, De Martino E, de Tommaso M, Deus J, Domin M, Egorova-Brumley N, Elliott J, Fanton S, Fauchon C, Flor H, Franz CE, Gatt JM, Gerdhem P, Gilman JM, Gollub RL, Govind V, Graven-Nielsen T, Håkansson G, Hales T, Haswell C, Heukamp NJ, Hu L, Huang L, Hussain A, Jensen K, Kircher T, Kremen WS, Leehr EJ, Lindquist M, Loggia ML, Lotze M, Martucci KT, Meeker TJ, Meinert S, Millard SK, Morey RA, Murillo C, Nees F, Nenadic I, Park HRP, Peng X, Ploner M, Pujol J, Robayo LE, Salan T, Seminowicz DA, Serian A, Slater R, Stein F, Stevens J, Strauss S, Sun D, Vachon-Presseau E, Valdes-Hernandez PA, Vanneste S, Vernon M, Verriotis M, Wager TD, Widerstrom-Noga E, Woodbury A, Zeidan F, Bhatt RR, Ching CRK, Haddad E, Thomopoulos SI, Thompson PM, Gustin SM
Journal Title: BMC Medicine
Published in: 2024
Authors: Senaratne DNS,
Thakkar B, Smith BH, Hales TG, Marryat L, Colvin LA
Journal Title: Neuropharmacology
Published in: 2024
Authors: Singleton S, Dieterle C, Walker DJ, Runeberg T, Oswald AS, Rosenqvist G, Robertson L, McCarthy T, Sarkar S, Baptista-Hon D, Hales TG
Journal Title: Pain
Published in: 2023
Authors: Singleton S, Sneddon C, Bakina A, Lambert JJ, Hales TG
