Publications
We have developed a Pain and Childhood Adversity questionnaire for us in the LBC1936 cohort. This has been completed by 225 of the participants is is now undergoing analysis.
2022 (and still active)
We are linking MRI datasets in Generation Scotland, Lothian Birth Cohort 1936 and Juvanile Ideopathic Arthritis patients to pain outcomes looking for biomarkers of vulnerability. This involves linkage, analysis and quality control.
2023 (still active)
Led by Professor Gary Macfarlane: Identification of qualitative literature assessing the relationship between adverse events in childhood and chronic widespread pain in adults using a search strategy in public datasets.
2024 (still active)
Further Findings
Arthritis UK
This is an extension of work started by CAPE
Research Datasets, database and Models
The dataset was collected as part of the CAPE study. It consists of pseudonymised data in 75 young adults with Juvenile Idiopathic Arthritis who have either high or low persistent pain. It includes: – detailed pain history. – multiple patient-reported outcome measures based on validated questionnaires assessing adverse childhood experiences, quality of life, function, psychosocial and cognitive factors. – Quatitative Sensory Testing data (QST; 13 measures + CPM task) assessing somatosensory function and sensitivity across a range of joints and muscles. – brain MRI data (T1, resting state fMRI, diffusion MRI, task fMRI: Reward task and Fearful Faces task). Collecting a broad range of information is important for increasing understanding of difficult-to-manage chronic pain. The dataset will be made publicly available after it has been finalised and initial results published.